It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and other cancers. It is the first member of a new class of agents that act by specifically inhibiting a certain enzyme that is characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing all rapidly dividing cells. In CML Glivec 400 Mg Buy Online India, the enzyme tyrosine kinase is stuck in the "on" position. Imatinib binds to the site of tyrosine kinase activity, and prevents its activity.